gudkov писал(а):Аня писал(а):А вообще по какой причине дутастерид ( аводарт) противопоказан женщинам?
( Так пишут в аннотации )
Только по причине того, что на фоне приема данных средств вы можете забеременеть и родить вместо пацана гермафродита
Если детей в планах нет, то можно принимать сколько влезет.
А вот я прочитала, ты где-то здесь раньше комментировал, что дутастерид повышает тестостерон.
А это не является противопоказанием для женщин ?
А еще прочитала про прием финастерида ( дутастерида )и рак груди:
An example of increased rates of male breast cancer associated with increased estrogen-to-testosterone ratios can be seen in men with Klinefelter's syndrome, who are 50 times more likely to develop breast cancer than their normal counterparts (4). This ratio may be affected by finasteride (Proscar), which has been widely marketed and used to treat benign prostate hyperplasia (BPH). Proscar shrinks androgen-dependent prostate tissue by inhibiting steroid 5α-reductase, an enzyme that converts testosterone to dihydrotestosterone (DHT). However, inhibition of DHT production alters the estrogen-to-androgen ratio and may also increase the risk of gynecomastia and male breast cancer. Reports to the U.S. Food and Drug Administration (FDA) from June 1992 through February 1995 showed that gynecomastia had been observed in 214 men receiving Proscar therapy. Two of these men were subsequently found to have invasive ductal breast carcinoma.
As this patient and his physician, we strongly recommend that the FDA require that information about the possible association between male breast cancer and Proscar be clearly stated in the manufacturer's patient information leaflet for prescriptions and in its advertisements. Proscar has been well established to improve quality of life in men suffering from BPH. Patients and their physicians need to be better informed about this potential life-threatening risk. Men who take Proscar need to be aware of any changes in their breasts and report these changes immediately to their physicians.
Это про мужчин. А у женщин как? механизмы ведь похожие...
Как раз в размерах той самой погрешности.