Azelaic acid 5% (Azelex™, Finacea™, Finevin®)

[kafir]

MINOXIDIL 12.5% + AZELAIC ACID

An Introduction to Minoidil 12.5% + Azelaic Acid Cream

Minoxidil 12.5% with Azelaic Acid (AA) cream is contains
12.5% Minoxidil and 5% Azelaic acid and has been exclusively developed by the Belgravia Pharmacy to treat stubborn cases of male and female pattern hair loss and Alopecia Areata, amongst other conditions. As Minoxidil is dose dependent, the 12.5% preparation is in most cases specifically beneficial in areas which include the temples, frontal hairline, or in some cases patches on the vertex or crown. Minoxidil 12.5% + AA is also beneficial to these areas as it is easy to apply due to its thick texture.

How Does Minoxidil 12.5% with Azelaic Acid 5% Work?

Minoxidil acts as a vasodilator and increases blood flow to the hair roots which encourages hair growth. Azelaic Acid is a natural substance found in some whole grains and in trace amounts in the human body.
Azelaic Acid acts as an inhibitor of the enzyme 5 alpha reductase, which converts testosterone to dihydrotestosterone (DHT). DHT is responsible for damaging the hair follicles and restricting growth. This reduction of DHT in the scalp encourages hair growth.

The combination of minoxidil and azelaic acid is highly complimentary. Minoxidil ensuring enough blood is being delivered to the follicles, and azelaic acid making sure the blood is in fit condition to ensure healthy hair growth .

Can Minoxidil 12.5% + AA be Used With Any Other Medications?

Over years of treating thousands of hair loss sufferers, Belgravia has found that the combination of more than one medication ensures the best results. Minoxidil 12.5% + AA can be used alongside propecia or minoxidil 5% + MPG, as well as hair vitalics and our other ‘boosters’ to ensure the highest chances of maximum re-growth.

Side Effects

Like other drugs there can be side effects from the use of Minoxidil 12.5% + AA for hair loss. During the past ten years of treating tens of thousands of men and women at the Belgravia Centre with minoxidil we estimate less than one in one hundred (1%) incidents of side effects. Side effects ranged from mild facial hair growth, headaches, rashes and palpitations. All were mild and needed no medical treatment. They either diminished in a short time during minoxidil use, or shortly after ceasing usage of minoxidil.

If any mild hair growth in unwanted areas is experienced from minoxidil 12.5% + AA (such as the face), Belgravia’s pharmacy can prescribe an FDA approved cream proven to reduce hair growth at the areas of application.

12.5% MINOXIDIL AND AZELAIC ACID 5% IS A PRESCRIPTION-ONLY TREATMENT

The Belgravia Trichological Centre

[kafir]

Том 02/N 8/2002 ФАРМКРУЖОК
Акне как проявление синдрома гиперандрогении: методы коррекции
С.И. Роговская, А.В.Телунц, И.С.Савельева

Научный центр акушерства, гинекологии и перинатологии РАМН (дир. – акад. РАМН, проф. В.И. Кулаков), Москва

Функции андрогенов в организме
Половые гормоны стероидного строения – андрогены играют важную роль в жизнедеятельности организма. Достижения последних лет в области эндокринологии и молекулярной биологии позволили установить, что рецепторы к андрогенам и, следовательно, зависимость от активности данных гормонов имеются во многих органах не только у мужчин, но и у женщин. Было показано участие этих гормонов в созревании костной ткани, регуляции секреции гонадотропинов и синтеза липидов, выработке эндорфинов, факторов роста, инсулина и других биологических субстанций. Наряду с анаболическим эффектом андрогены регулируют либидо и половую потенцию. В физиологических концентрациях андрогены участвуют в механизме регрессии фолликула в яичниках и определяют рост волос на лобке и в подмышечных впадинах. Особый интерес представляет стимулирующий эффект андрогенов на функцию сальных желез и волосяных фолликулов.

Где вырабатываются андрогены
Андрогены могут секретироваться яичниками, надпочечниками и другими органами и тканями. Клинические проявления гиперандрогении чрезвычайно многообразны, и основная задача – выявление источника гиперандрогении – зачастую является весьма сложной. Опухоли надпочечников и яичников, гермафродитизм, гиперплазия коры надпочечников, поликистозные яичники – вот неполный перечень тех сложных заболеваний и синдромов, которые сопряжены с увеличением синтеза андрогенов.

... Лечение акне может дополняться препаратами для местного применения, в частности азелаиновой кислотой (скинорен). Скинорен нормализует процесс кератинизации в стенке волосяного фолликула, оказывает противовоспалительное противомикробное действие в отношении Propionibacterium acneах.
...
http://www.consilium-medicum.com/media/ ... 8/28.shtml

[kafir]

Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases
Journal Archives of Dermatological Research
Publisher Springer Berlin / Heidelberg
ISSN 0340-3696 (Print) 1432-069X (Online)
Subject Medicine
Issue Volume 283, Number 3 / May, 1991
Category Original Contributions
DOI 10.1007/BF00372056
Pages 162-166
Online Date Friday, December 10, 2004

Original Contributions
Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases

H. Akamatsu1, J. Komura1, Y. Asada1, Y. Miyachi2 and Y. Niwa1 Contact Information
(1) Department of Dermatology, Kansai Medical University, Japan
(2) Department of Dermatology, Faculty of Medicine, Kyoto University, Japan
(3) Niwa Institute for Immunology, 4-4 Asahimachi, Tosashimizu, 787-03 Kochi-ken, Japan

Received: 11 August 1990
Summary It has been shown that acne, hyperpigmentation and lentigo malignant are more or less related pathogenetically to reactive oxygen species (ROS). It has recently been reported that azelaic acid is effective in treating these conditions and that it possesses anti-enzymatic and anti-mitochondrial activity, including cytochrome-P450 reductase and 5agr-reductase in microsomal preparations with nicotinamide adenine dinucleotide phosphate (NADPH). We therefore investigated the effects of azelaic acid on human neutrophil functions, such as chemotaxis, phagocytosis and ROS generation. ROS generation in a cell-free system was also assessed. The results revealed that neutrophil chemotaxis and phagocytosis as well as ROS generated in a xanthine — xanthine-oxidase system were not significantly changed in the presence of azelaic acid. However, azelaic acid markedly decreased O 2 –and OH generated by neutrophils. It may be concluded that the reported clinical effectiveness of azelaic acid is partly due to its inhibitory action on neutrophil-generated ROS, leading to a reduction both in oxidative tissue injury at sites of inflammation and in melanin formation.

Key words Azelaic acid - Neutrophil functions - Free radical generation - Acne inflammation - Hyperpigmentation

References
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2. Bladon PR, Burke BM, Cunliffe WJ, Forster RA, Holland KT, King K (1986) Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline. Br J Dermatol 114:493–499

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19. Miyachi Y, Imamura S, Niwa Y (1986) Anti-oxidant action of metronidazole: a possible mechanism of action in rosacea. Br J Dermatol 114:231–234

20. Miyachi Y, Yoshioka A, Imamura S, Niwa Y (1986) Effect of antibiotics on the generation of reactive oxygen species. J Invest Dermatol 86:449–453

21. Miyachi Y, Yoshioka A, Imamura S, Niwa Y (1987) Anti-inflammatory activities of tetracyclines are partly exerted by their anti-oxidant effect. In: Urabe H, Kimura M, Yamamoto K, Ogawa H (eds) Proceedings of the IVth International Congress of Pediatric Dermatology. University of Tokyo Press, Tokyo, pp 291–294

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26. Nazzaro-Porro M, Passi S, Zina G, Bernengo A, Breathnach AS, Morpurgo G (1980) Effect of azelaic acid on human malignant melanoma. Lancet II:1109–1111

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31. Niwa Y, Miyake S, Sakane T, Shingu M, Yokoyama M (1982) Auto-oxidative damage in BehÇet's disease — endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils. Clin Exp Immunol 49:247–255

32. Niwa Y, Sakane T, Shingu M, Yokoyama MM (1983) Effect of stimulated neutrophils from the synovial fluid of patients with rheumatoid arthritis on lymphocytes — a possible role of increased oxygen radicals generated by the neutrophils. J Clin Immunol 3:228–240

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39. Pathak MA, Ciganek ER, Wick M, Sober AJ, Farinelli WA, Fitzpatrick TB (1985) An evaluation of the effectiveness of azelaic acid as depigmenting and chemotherapeutic agent. J Invest Dermatol 85:222–228

40. Pehamberger H (1984) Das maligne Melanom der Haut, Prognose und Therapie. W. Zuckschwerdt Verlag, Vienna, pp 46–52

41. Picardo M, Passi S, Sirianni MC, Fiorilli M, Russo GD, Cortesi E, Barile G, Breathnach AS, Nazzaro-Porro M (1985) Activity of azelaic acid on cultures of lymphoma- and leukaemia-derived cell lines, normal resting and stimulated lymphocytes, and 3T3 fibroblasts. Biochem Pharmacol 34:1653–1658

42. Rach P, Töpert M (1986) Pharmacologic investigation of azelaic acid. J Invest Dermatol 86:327

43. Robins EJ, Breathnach AS, Ward BJ, Bhasin Y, Ethridge L, Nazzaro-Porro M, Passi S, Picardo M (1985) Effect of dicarboxylic acids on Harding-Passey and Claudman S91 melanoma cells in tissue culture. J Invest Dermatol 85:216–221

44. Root RK, Metcalf JA (1972) H2O2 release from human granulocytes during phagocytosis. J Clin Invest 60:1266–1279

45. Sasaguri Y, Morimatsu M, Kanoshita T, Nakashima T, Inagaki T, Yagi K (1985) Difference in susceptibility to injury by linoleic acid hydroperoxide between endothelial and smooth muscle cells of arteries. J Appl Biochem 7:70–78

46. Schallreuter KU, Wood JM (1989) Free radical reduction in the human epidermis. Free Radic Biol Med 6:519–532

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48. Stossel TP (1973) Evaluation of opsonic and leukocyte function with a spectrophotometric test in patients with infection and with phagocytic disorders. Blood 42:121–130

49. Yagi K (1984) Increased serum lipid peroxides initiate atherogenesis. Bio Essays 1:58–60

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[kafir]

Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata: A Pilot Study

Authors: Sasmaz, Sezai1; Arican, Ozer1

Source: American Journal of Clinical Dermatology, Volume 6, Number 6, 2005, pp. 403-406(4)

Publisher: Adis International

Key:
Free Content - Free content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:
Background: Although topical azelaic acid has been previously used for the treatment of alopecia, no controlled trials of azelaic acid for this condition have been conducted to date.

Objective: The goal of this study was to determine the efficacy, tolerability, and safety of azelaic acid treatment in patients with patchy alopecia areata (AA) in comparison with anthralin (dithranol) treatment.

Subjects and methods: This study included 31 subjects with patchy AA who did not receive any treatment for at least 1 month prior to the study. Demographic and clinical characteristics of these subjects were recorded at baseline. Subjects were randomized to apply either 20% azelaic acid (15 subjects) or 0.5% anthralin (16 subjects) for 12 consecutive weeks. In a subsequent 8-week follow-up period no cream was applied. Two independent investigators performed an efficacy evaluation with clinical examination using a terminal hair regrowth score (RGS) with a scale ranging from 0 (inadequate response) to 2 (complete response) at week 20. Partial response was accepted as score 1.

Results: Both groups were well matched for the relevant demographic and clinical indicators affecting treatment response at baseline. All subjects completed the trial. At week 20 the RGS was 1.27 ± 0.9 in the azelaic acid group versus 1.37 ± 0.8 in the anthralin group (p > 0.05). A complete response was observed in 53.3% of cases in the azelaic acid group (8 of 15) compared with 56.2% (9 of 16) in the anthralin group (p > 0.05). No serious adverse events were observed in either group during the study.

Conclusion: The present pilot study showed that the use of azelaic acid gave similar results to anthralin with regard to hair regrowth, and that it can be an effective topical therapy for patchy AA. More extensive trials are necessary, however, to reach a definitive conclusion.

Keywords: Alopecia areata; Azelaic acid; Dithranol

Document Type: Research article

Affiliations: 1: Department of Dermatology, School of Medicine, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey

http://www.ingentaconnect.com/content/a ... 6/art00007

[vovach777]

kafir
Жжош!

Скинорен, крем 20%
Шеринг / Германия

доступная вещь - 500 руб. Мне нравится продукция шеринг. Так и подмывает разбодяжить Скиноген их Андрокуром-депо...

Спасибо за актуальные посты.

[Alan4ik]

поднял старую тему в свете необходимости закупки минокса в ближ будущем.
на ибее встречается минокс в сочетании с азелаиновой кислотой. вопрос к тем, кто пробовал (мнение остальных не интересует). кто пробовал минокс в сочетании с этим компонентом, и без последнего. есть ли разница? как кожа головы реагировала на азелку?

[agaBorec]

шо за бред тут развели?

Никакой конкретики от автора! в помойку..

[vixxxx]

поднял старую тему в свете необходимости закупки минокса в ближ будущем.
на ибее встречается минокс в сочетании с азелаиновой кислотой. вопрос к тем, кто пробовал (мнение остальных не интересует). кто пробовал минокс в сочетании с этим компонентом, и без последнего. есть ли разница? как кожа головы реагировала на азелку?

Я пробовал Дуалген 15% минокс + 5% азелаин.к-та - 6 месячный курс. Эффект хуже чем 5% миноксидил Кёркланд - начал терять что выростил. Вернулся к керкланду - ситуация улучшилась, вернул выращенное до Дуалгена.
Вот такое субъективное мнение.

[jettset]

Как долго ты его применял?

[Царьков_Евгений]

6 мес. Курс раз такой купил, выбрасывать думаю бы не стал.... Наверно синхра была. (Мин то наносил более сильный, чем раньше, вот и вызвал синхру). Надо выслушать знатоков...

[denis123]

Вот такое субъективное мнение.

А у тебя самого какие есть предположения?

[marina volosataja]

Тем более статья - реклама.

azelaic acid - eto veshestvo ne imejusheje patenta, ego mogut delat' vse komu ne len'

u menja net ni acne, ni seborrei, a to chto nado prinimat' dolgo, to i ot eucapila cherez 3 nedeli nichego novogo bystro ne vyrastit

shas prochital instrukziju k Finacea - napisano chto mozhno primenjat' dlitelnyje periody, i acne vernetsja posle okonchanija primenenija, t.e. eto tipichny antiandrogen.

Мы с мужем применяем миноксидил 5% + азелаин 5% + РетинА. (Generic Minoxidil 5% Azelaic Acid 5% RetinA 0,25% 140 ml) В эффективности азелаина и витамина А я не сомневаюсь

[denis123]

Мы с мужем применяем миноксидил 5% + азелаин 5% + РетинА. (Generic Minoxidil 5% Azelaic Acid 5% RetinA 0,25% 140 ml) В эффективности азелаина и витамина А я не сомневаюсь

Типа здесь твоя реклама прокатит - не хочу тебя разочаровывать но нет.

[marina volosataja]

поднял старую тему в свете необходимости закупки минокса в ближ будущем.
на ибее встречается минокс в сочетании с азелаиновой кислотой. вопрос к тем, кто пробовал (мнение остальных не интересует). кто пробовал минокс в сочетании с этим компонентом, и без последнего. есть ли разница? как кожа головы реагировала на азелку?

Мы с мужем применяем миноксидил 5% + азелаин 5% + РетинА. (Generic Minoxidil 5% Azelaic Acid 5% RetinA 0,25% 140 ml) В эффективности азелаина и витамина А я не сомневаюсь Пять лет уже нет проблем с выпаденим Я добавляю для себя 50% водки чтобы получит примерно 2% и с эканомить.

[vixxxx]

Вот такое субъективное мнение.

А у тебя самого какие есть предположения?

1) мин 15% очень вязкий, его труднее наносить и мал эффект в сочетании с дермароллером
2) мин 5% я наношу в бОльшем кол-ве чем 15% мин, потому что он дешевле.