Lawyer писал(а):
Дело в том, что это физически невозможно. Чтобы волосы отреагировали даже на внешнее воздействие нужно никак не меньше пары месяцев, раньше это просто нереально.
Androgen action: molecular mechanism and medical application. 85 REFS
AUTHOR Liao S
ORGANISATION Ben May Institute, Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA.
SOURCE J Formos Med Assoc 1994 Sep; 93 (9): 741-51
LANGUAGE OF ORIGIN English
ABSTRACT
Androgen action in many organs, such as prostate and skin, is dependent on the conversion of testosterone by 5 alpha-reductase to 5 alpha-dihydrotestosterone. 5 alpha-Dihydrotestosterone then binds to the androgen receptor to regulate specific gene expression. Inhibitors of 5 alpha-reductase are useful for the selective treatment of prostatic cancer, benign prostate hyperplasia, acne, baldness and female hirsutism, without affecting spermatogenesis, sexual behavior and smooth muscle growth, that do not require the conversion of testosterone to 5 alpha-dihydrotestosterone. Certain unsaturated fatty acids, such as gamma-linolenic acid, are potent 5 alpha-reductase inhibitors, suggesting a linkage between unsaturated fatty acids and androgen action. Mutations in androgen receptor genes are responsible for many cases of androgen-insensitivity. In some prostate cancer cells, some antiandrogens may act like androgens in stimulating the proliferation of the cancer cells because these antiandrogens can bind to a mutated androgen receptor and transactivate target genes. Prostate cancers are usually androgen-dependent initially but can lose dependency and responsiveness. Tumor cells which are resistant to endocrine therapy ultimately proliferate. Androgen-independent or androgen-repressive cells can arise from androgen-sensitive prostate cancer cells by changes in specific gene expression over time in a clonal isolate. This change in androgen responsiveness was accompanied by a change in androgen receptor expression and transcriptional activity as well as expression of some oncogenes.
(AUTHOR) MJTR: Androgens PH. MNTR: Androgen Antagonists ME. Androgens CH. Androgens GE. Androgens ME. Base Sequence. Human. Male. Molecular Sequence Data. Prostatic Neoplasms GE. Prostatic Neoplasms ME. Prostatic Neoplasms TH. Receptors, Androgen CH. Receptors, Androgen GE. Receptors, Androgen PH. Skin Diseases GE. Skin Diseases ME. Support, U.S. Gov't, P.H.S.. Testosterone 5-alpha-Reductase AI. Testosterone 5-alpha-Reductase GE. Testosterone 5-alpha-Reductase ME. Testosterone 5-alpha-Reductase PH. JOURNAL ARTICLE. REVIEW. REVIEW LITERATURE RNUM: EC 1.3.99.5 (Testosterone 5-alpha-Reductase); 0 (Androgen Antagonists); 0 (Androgens); 0 (Receptors, Androgen) GEOT: TAIWAN IDEN: ISSN: 0929-6646. JOURNAL-CODE: BLQ. ENTRY-DATE: 950606. NIH-GRANT-NUMBER: DK 37694DKNIDDK. DK41670DKNIDDK. CA 59073CANCI. IM-DATE: 9508.
Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase.
AUTHOR Liang T; Liao S
ORGANISATION Ben May Institute for Cancer Research and the Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, U.S.A.
SOURCE J Invest Dermatol 1997 Aug; 109 (2): 152-7
LANGUAGE OF ORIGIN English
ABSTRACT
Certain unsaturated aliphatic fatty acids, such as gamma-linolenic acid, inhibit 5alpha-reductase activity in vitro and in vivo. Hamster flank organ growth, as measured by the increase in the area of pigmented macule, is dependent on androgen. When one of the paired flank organs of a castrated hamster was treated topically with testosterone, the treated organ, but not the contralateral flank organ, became larger and darker. Topical application of gamma-linolenic acid to the testosterone-treated flank organ suppressed this testosterone effect. Other fatty acids that were not inhibitors of 5alpha-reductases were not active. Topical treatment of hamster flank organs with 5alpha-dihydrotestosterone also stimulated the growth of the organ. This 5alpha-dihydrotestosterone-dependent activity, however, was not significantly affected by gamma-linolenic acid, suggesting that flank organ growth was dependent on 5alpha-dihydrotestosterone and that gamma-linolenic acid acted by inhibiting 5alpha-reductase. With intact male hamsters, the endogenous androgen-dependent growth of flank organs is also suppressed by topical treatment with gamma-linolenic acid. The effect of gamma-linolenic acid is localized at the site of its application; topical application of gamma-linolenic acid did not affect the androgen-dependent growth of other organs such as testis, epididymis, seminal vesicle, and prostate. gamma-Linolenic acid, with low toxicity and absence of systemic effect, therefore may be potentially useful for treatment of androgen-dependent skin disorders.
(AUTHOR) MJTR: gamma-Linolenic Acid PD. Enzyme Inhibitors PD. Growth DE. Mesocricetus AH. Oxidoreductases AI. MNTR: Administration, Topical. Animal. Hamsters. Male. Models, Biological. Orchiectomy. Pigmentation DE. Sebaceous Glands PH. Support, U.S. Gov't, P.H.S.. JOURNAL ARTICLE RNUM: EC 1. (Oxidoreductases); EC 1.3.1.22 (cholestenone 5 alpha-reductase); 0 (Enzyme Inhibitors); 506-26-3 (gamma-Linolenic Acid) GEOT: UNITED STATES IDEN: ISSN: 0022-202X. JOURNAL-CODE: IHZ. ENTRY-DATE: 970820. NIH-GRANT-NUMBER: DK41670DKNIDDK. CA58073CANCI. JOURNAL-SUBSET: M X. IM-DATE: 9710. ACCE: 97385005
, это типа еслиб я регейном голову мазал и тутже шампунем ее мыл. 
